Scientists from the Single-Cell Center at the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences have developed a Digital Colony Picker (DCP)-based microfluidic platform to meet this need. The platform integrates arrayed single-cell capture, on-chip incubation, real-time bright-field and fluorescence detection, and precise target-cell recovery in one streamlined workflow. Differences between individual cells play a critical role in mammalian development, immune responses, and disease progression. However, tools capable of capturing, monitoring, and recovering selected cells for downstream analysis are often complex...
Researchers at the Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences discovered that the E3 ubiquitin ligase PTR1 coordinates carotenoid, sterol, and lipid metabolism in yeast. PTR1 forms a regulatory network with the White Collar Complex and interacting proteins, balancing biosynthetic flux. Conserved across eukaryotes, PTR1-mediated ubiquitination represents a general mechanism for metabolic regulation. These findings expand E3 ligase functions beyond protein turnover and offer new strategies for optimizing microbial production of astaxanthin, sterols, and lipids. Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences (CAS), have identified a conserved ubiquitin-mediated regulatory mechanism that coordinates metabolic flux among multiple biosynthetic pathw...
Scientists from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences, in collaboration with Tsinghua University, the Chinese Academy of Agricultural Sciences, Beijing PhaBuilder Biotechnology Co., Ltd., and Qingdao Single-Cell Biotech Co., Ltd., have developed a “process ramanomics” platform that transforms industrial fermentation tanks from opaque “black boxes” into transparent, data-rich environments. A collaborative research team led by the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences has developed a new "process ramanomics" platform. This technology transforms industrial fermentation tan...
That is essentially the challenge of separating critical heavy metals like uranium, copper, and gold from complex industrial liquids, where they are mixed with highly similar competing ions. Imagine an exclusive event where the invited VIPs and the party-crashers look virtually identical, wearing the exact same outfits and standing at the exact same height. How do you instantly let the true VIPs through while blocking the imposters? T...
The study, published on March 27 in the journal of Analytical Chemistry, introduces a multifeature antifungal susceptibility testing platform (MAFST), designed to address a longstanding challenge in clinical mycology: current susceptibility tests are often too slow, labor-intensive, or inconsistent across fungal species and drug classes. According to a new study published in Analytical Chemistry on March 27, Chinese scientists have developed a rapid and broadly applicable platform for antifungal susceptibility testing, offering a potential new route to faster and more informative ...
Scientists from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) and the Tianjin Institute of Industrial Biotechnology (TIB), both part of the Chinese Academy of Sciences, have introduced a rapid, high-throughput error-correction platform designed to improve the accuracy of synthetic DNA. Scientists from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) and the Tianjin Institute of Industrial Biotechnology (TIB) of CAS, have developed a rapid, high-throughput error-correc...