Protein Design Group----Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences

Introduction

Protein Design Group was established in 2010 and currently has 16 members, including 8 staff members, from 8 universities and scientific research institutions at home and abroad. The research background covers chemistry, physical chemistry, biochemistry and molecular biology.There are now 1 postdoc,6 doctoral students, 2 master students in the lab. Besides that,6 doctoral students and 5 master students have been trained, who are now working in universities, scientific research institutions and biological enterprises respectively.

Website: http://english.qibebt.cas.cn/pe/pi/201511/t20151118_156007.html

Director of Center/Group

Prof. YAO Lishan

Professor YAO Lishan obtained his Ph.D in chemistry from Michigan State University in 2006. From 2006 to 2010, he worked as postdoctoral researcher associate in National Institutes of Health. In May 2010, he joined Qingdao Institute of Bioenergy and Bioprocess Technology, CAS as a faculty member. He is currently a professor and the leader of Protein Design group. He has published over 40 research papers in leading journals such as JACS and ACIE, and applied for 3 patents.

Research Interest

1. Developing novel NMR methods to study protein interactions;

2. Using computational methods to study protein dynamics and interaction mechanisms;

3. Designing proteins and enzymes with improved properties.

Research Fields

Nuclear Magnetic Resonance (NMR) spectroscopy methods;Computer Aided Drug Design;Directed evolution of enzymes

Representative Research

Developing a novel J-coupling measurement method to study the van der Waals interactions;

Developing a salt bridge measurement method to significantly improve the accuracy;

Developing a novel H/D exchange method to study the h-bond cooperativity;

Designing a new NMR method to measure protein electrostatics in cell environment and illustrate the mechanism of weak interactions between the protein and its environment.

These studies have systematically established the methodology for atomic interaction measurements which help understand the properties of protein atomic interactions.

Contact

yaols@qibebt.ac.cn

Research Divisions