System Microbial Engineering Group----Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences

Introduction

System Microbial Engineering Group was established in September 2020. The group focuse on the basic and application research of demand-oriented open fermentation. The research scope covers the fields of microorganisms, metabolic engineering, characterization and control of mixed bacteria succession, fermentation, etc., and products involve bio-based materials and chemicals, tobacco, etc. The group have received multiple project support from the National, Provincial Department of Science and Technology, China Tobacco Hainan Provincial Department, Chinese Academy of Sciences and Research Institutes. The research team currently has 17 staff and students, including 5 employees (4 doctors, 1 master) and 12 students (8 of whom are jointly trained). In 2020, the group was awarded the honorary title of "Youth in a Good Team" in Qingdao . In recent years, the group has published more than 70 papers in Nature Communications, Natural Product Reports and other magazines, and applied for 33 patents.

Website: http://sme.qibebt.ac.cn/

Director of Center/Group

Prof. ZHANG Haibo

Professor ZHANG Haibo obtained his PhD in microbiology from State Key Laboratory of Microbial Technology, Shandong University in 2010. In July 2010, he joined Qingdao Institute of Bioenergy and Bioprocess Technology, CAS as a faculty member. From 2013 to 2017, he worked as an associate Professor in the Biobased Materials department. He visited Massachusetts Institute of Technology as a visiting scholar in 2016. He is currently a professor and the leader of System Microbial Engineering group. He has published over 50 research papers on leading journals such as Nature Communications, Natural Product Reports, Biotechnology Advances, Biotechnology for Biofuels, Macrobial Cell Factories and etc, and applied for more than 30 patents. He got the "Min Enze Energy and Chemical Progress Award for Young Scholar" in 2017.

Research Interest

1. Biosynthesis of basic fine chemicals, such as isoprene, 2,3-butanediol, styrene and 2-phenylethanol, in engineered microorganisms.

2. Biosynthesis of terpene-based high-density biofuels, such as pinene, sabinene, farnesene and terpinene, in engineered microorganisms.

3. Developing biosensor, bacterial microcompartments and phospholipid metabolism regulation technologies for enhancing terpene production in engineered microorganisms.

Research Fields

1. Microbial Metabolic Engineering;

2. Characterization and Isolation of Environmental Microorganisms;

3. Open Fermentation.

Representative Research

1. Microbial metabolism engineering: construct high-efficiency catalytic strains and catalytic methods, analyze regulation mechanisms, and improve strain efficiency.

2. Characterization and isolation of environmental microorganisms: characterization and control of the succession of mixed bacteria, with the help of low-cost sequencing to characterize the succession, and the use of customized separation to obtain relevant.

3. Open fermentation: establish a low-cost single or mixed open fermentation method, and investigate the scientific issues in open fermentation.

Contact

zhanghb@qibebt.ac.cn

Research Divisions