XU Jian received a B.S. in Biotechnology from Peking University in 1997, and a M.S. in Computer Science and a Ph.D in Biochemistry from Washington University in St. Louis in 2003. After serving as Research Instructor at Genome Institute of Washington University, he joined Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT), Chinese Academy of Sciences (CAS) in 2008, and has been the founding director of Single-Cell Center (http://www.single-cell.cn/) of QIBEBT. The Center has been developing a new generation of single-cell analysis instruments based on the Ramanome concept and the Raman-activated Cell Sorting technologies. Via these innovative research tools, Dr. Xu and his colleagues are delineating and designing key metabolic processes such as microalgal CO2 fixation and human-microbe symbiosis, across the biological hierarchy of single-cell, population and consortium. He has published over 100 papers on peer-reviewed journals such as Science, Cell Host & Microbe, Nature Communications, PNAS, PLoS Biology, PLoS Genetics, Plant Cell, Mol Plant, ISME Journal, Analytical Chemistry, etc., with over 7000 citations (for a full list of publications, please see https://www.researchgate.net/profile/Jian_Xu8). He is a senior editor of mSystems. He received a number of career awards from National Natural Science Foundation of China (NSFC), Ministry of Science and Technology of the People’s Republic of China (MOST) and CAS, including the National Science Fund for Distinguished Young Scholars (2014), National Young-Scientist Award for Science and Technology (2016) and VCANBIO Award for Biosciences and Medicine (2016). He has mentored over 20 doctoral students and postdoctoral scholars, and was recognized for excellence in mentorship via the 2013 CAS 100 Best Ph.D Thesis Award and the 2014 UCAS-BHPB Mentorship Award. Please refer to http://www.single-cell.cn/ for more details.
1. Single-cell analysis and instrument development
2. Microalgal synthetic biology for carbon dioxide fixation and biofuels
3. Human microbiota and health
1. Emerging trends for microbiome analysis: from single-cell functional imaging to microbiome big data, (2017). XU J.,MA B., SU X., HUANG S., XU X., ZHOU X., HUANG W., KNIGHT R., Engineering, 3, 66
2. Label-free, rapid and quantitative phenotyping of stress response via ramanome, (2016 ). TENG L., WANG X.,WANG X., REN L., WANG T., WANG Y., JI Y., HUANG W., XU J., Scientific Reports, 6, 34359
3. Producing designer oils in industrial microalgae by rational modulation of co-evolving type-2 diacylglycerol acyltransferases, (2017). XIN Y., LU Y., LEE Y., WEI L., JIA J., WANG Q., WANG D.,BAI F., HU H., HU Q., LIU J., LI Y., XU J., Molecular Plant, 10, (12), 1523-1539
4. RNAi-based targeted gene-knockdown in model oleaginous microalgae Nannochloropsis spp., (2017). WEI L., XIN Y., WANG Q., YANG J., HU H., XU J., The Plant Journal, 89, (6), 1236-1250
5. Genome editing of model oleaginous microalgae Nannochloropsis spp. by CRISPR/Cas9, (2016). WANG Q., LU Y.,XIN Y., WEI L., HUANG S., XU J., The Plant Journal, 88, (6), 1071-1081
6. Raman activated cell sorting based on dielectrophoretic single-cell trap and release, (2015). ZHANG P., REN L.,ZHANG X., SHAN Y., WANG Y., JI Y., YIN H., HUANG W., XU J.,MA B., Analytical Chemistry, 87, (4), 2282-2289
7. Prediction of early childhood caries via spatial-temporal variations of oral microbiota, (2015). TENG F.,YANG F., HUANG S., BO C., XU Z., AMIR A., KNIGHT R., LING J., XU J., Cell Host & Microbe, 18, (3), 296.
8. Cellulosome stoichiometry in clostridium cellulolyticum is regulated by selective rna processing and stabilization, (2015). XU C., HUANG R., TENG L., JING X., HU J., CUI G., WANG Y., CUI Q., XU J., Nature Communications, 6, 6900.
9. Predictive modeling of gingivitis severity and susceptibility via oral microbiota, (2014). HUANG S., LI R., ZENG X., HE T., ZHAO H., CHANG A., BO C., CHEN J., YANG F., KNIGHT R., LIU J., DAVIS C., XU J., ISME Journal, 8, 1768.
10. Choreography of transcriptomes and lipidomes of Nannochloropsis reveals the mechanisms of oil synthesis in microalgae, (2014). LI J., HAN D., WANG D., NING K., JIA J., WEI L., JING X., HUANG S., CHEN J., LI Y. et al., Plant Cell, 26, 1645.
11. Nannochloropsis genomes reveal evolution of microalgal oleaginous traits, (2014). WANG D., NING K., LI J., HU J., HAN D., WANG H., ZENG X., JING X., ZHOU Q., SU X. et al., PLoS Genetics, 10, (1), e1004094.