Quantitatively Studying the Effects of Cellulase Glycosylation
Lecture: Quantitatively Studying the Effects of Cellulase Glycosylation
Lecturer: Assistant Prof. Zhongping TAN, Department of Chemistry and Biochemistry, BioFrontiers Institute, University of Colorado, USA
Time: 10:00 am, Jun 16, 2015
Location: Meeting Room 205 of Administration Building
Introduction of Lecturer
Education Experiences:
2000-2005, Master and doctor degree, Chemicobiology, Columbia University
Supervisor: Prof. Virginia W. Cornish
1992-2000, Bachelor and master degree, Organic Chemistry, Peking University
Supervisor: Prof. Jianbo Wang
Research Experiences:
2011-now, Assistant Professor, Chemical Glycobiology, University of Colorado
2005-2011, Postdoctoral Fellow, Bioorganic Chemistry, Memorial Sloan-Kettering Cancer Center
Supervisor: Prof. Samuel J. Danishefsky
Tan’s Research Group: http://chem.colorado.edu/tangroup/
Research Focuses:
Tan’s lab studies the effects of glycosylation on protein structure and activity. Protein glycosylation is an important post-translational modification. It enhances the functional diversity of proteins and alters their conformation, stability and biological activity. However, because of the complexity of glycoproteins and glycan structures, establishing connections between glycan structures and their functions is difficult. Recently, we demonstrate that chemical glycobiology can be employed as a useful tool to determine the effects of protein glycosylation and the molecular mechanisms of these effects. The more precise understanding of protein glycosylation would aid in the development of enzymes and protein-based therapeutics with improved properties.
Selected Publications:
(1) “New methods for chemical protein synthesis”, X. Guan, P.K. Chaffey, C. Zeng, Z. Tan,* Top Curr Chem, 2015, 363, 155-192.
(2) “Specificity of O-glycosylation in enhancing the stability and cellulose binding affinity of Family 1 carbohydrate-binding modules”, L. Chen, M.R. Drake, M.G. Resch, E.R. Greene, M.E. Himmel, P.K. Chaffey, G.T. Beckham,* Z. Tan*, Proc Natl Acad Sci USA, 2014, 111, 7612-7617.
(3) “Glycosylated linkers in multi-modular lignocellulose degrading enzymes dynamically bind to cellulose”, C.M. Payne, M.G. Resch, L. Chen, M.F. Crowley, M.E. Himmel, L.E. Taylor, M. Sandgren, J. St？hlberg, I. Stals,* Z. Tan,* G.T. Beckham,* Proc Natl Acad Sci USA, 2013, 110, 14646-14651.
(4) “Total synthesis of human galanin-like peptide through an aspartic acid ligation”, X. Guan, M.R. Drake, Z. Tan*, Org Lett, 2013, 15, 6128-6131.
(5) “A convenient and efficient synthetic approach to mono-, di-, and tri-O-mannosylated Fmoc amino acids”, L. Chen, Z. Tan*, Tetrahedron Lett, 2013, 54, 2190-2193.
