Engineering Synthetic Biopathway and Reprogramming Codon Language
Lecture: Engineering Synthetic Biopathway and Reprogramming Codon Language
Lecturer: Assistant Prof. Jiantao GUO, Department of Chemistry, University of Nebraska-Lincoln, USA
Time: 9:00 am, Jun 15, 2015
Location: Meeting Room 205 of Administration Building
Introduction of Lecturer
Education Experiences:
Postdoctoral, The Scripps Research Institute
Postdoctoral, Michigan State University
Ph.D., Michigan State University
M.S., Nankai University
B.S., Nankai University
Guo’s Research Group: http://chemweb.unl.edu/guo/
Research Focuses:
(1) The use of non-natural amino acids in biochemical investigations and biomedical applications.
(2) The study of protein O-tyrosine sulfation.
(3) The control of protein assembly through biomolecular evolution.
(4) Biocatalysis.
Selected Publications:
(1) “Construction of a Live-Attenuated HIV- 1 Vaccine through Genetic Code Expansion”, Wang, N.; Li, Y.; Niu, W.; Sun, M.; Cerny, R.; Li, Q.;* Guo, J.*, Angew. Chem. Int. Ed., 2014, 126, 4967-4971. (This article was highlighted in Nature Chemistry.)
(2) “Expanding the Chemistry of Fluorescent Protein Biosensors by Genetic Incorporation of Unnatural Amino Acids”, Niu, W.; Guo, J.*, Mol. Biosyst., 2013, 9, 2961-2970.
(3) “An Expanded Genetic Code In Mammalian Cells With a Functional Quadruplet Codon”, Niu, W.; Schultz, P. G.; Guo, J.*, ACS Chem. Biol., 2013, 8, 1640-1645.
(4) “Unnatural Amino Acid Mutagenesis of Fluorescent Proteins”, Wang, F.; Niu, W.; Guo, J.*; Schultz, P. G.*, Angew. Chem. Int. Ed., 2012, 51, 10132-10135.
(5) “Evolution of Amber Suppressor tRNAs for Efficient Bacterial Production of Unnatural Amino Acid-Containing Proteins”, Guo, J.; Melan？on III, C. E.; Lee, H. S.; Groff, D.; Schultz, P. G., Angew. Chem. Int. Ed., 2009, 48, 9148-9151.
(6) “Addition of an α-Hydroxy Acid to the Genetic Code of Bacteria”, Guo, J.; Wang, J.; Anderson, J. C.; Schultz, P. G., Angew. Chem. Int. Ed., 2008, 47, 722-725. (This article was highlighted in Nature.)
(7) “Site-Specific Incorporation of Methyl- and Acetyl-Lysine Analogues into Recombinant Proteins”, Guo, J.; Wang, J.; Lee, J. S.; Schultz, P. G., Angew. Chem. Int. Ed., 2008, 47, 6399-6401. (This article was highlighted in “Faculty of 1000 Biology”.)
(8) “Biosynthesis of 1-Deoxy-1-imino-D-erythrose 4-phosphate: A Defining Metabolite in the Aminoshikimate Pathway”, Guo, J.; Frost, J. W., J. Am. Chem. Soc., 2002, 124, 528-529.
(9) “Kanosamine Biosynthesis: A Likely Source of the Aminoshikimate Pathway's Nitrogen Atom”, Guo, J.; Frost, J. W., J. Am. Chem. Soc., 2002, 124, 10642-10643.
