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BioEnergy Center
Applied Energy Center
CAS Key Laboratory of Biobased Materials
Location: Home>Research>Research System>BioEnergy Center>Enzyme Engineering
Enzyme Engineering Group

 

 

 

 

 

 

Group Leader: Prof. Dr. LI Shengying
Tel: 86-532-80662676
E-mail: lishengying@qibebt.ac.cn

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LI Shengying, Ph.D., Professor, Enzyme Engineering Group Leader at Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, the member of the “Thousand Young Talents Program”. He obtained his bachelor’s degree in Biology and master’s degree in Microbiology from School of Life Sciences, Xiamen University in 2000 and 2003, respectively. He earned his Ph.D. degree in Department of Medicinal Chemistry, College of Pharmacy at University of Michigan, Ann Arbor, USA in 2009. Due to his distinguished academic performance, Dr. Li was awarded with the “The National Award for Outstanding Self-financed Chinese Students Study Award” by China Scholarship Council in 2010. From 2010-2012, he was performing his postdoctoral research in Life Sciences Institute, University of Michigan. Concurrently, he served as a senior research scientist for Alluvium Biosciences Inc., where his efforts were focused on industrial strain improvement and microbial production of advanced biofuels. So far, he has published more than 20 research articles on a number of prestigious scientific journals such as Nature Chemistry, PNAS, JACS, JBC, and Chemistry & Biology. Since 2012, he has served as the Editorial Board Member for Journal of Industrial Microbiology and Biotechnology, and the scientific consultant for a number of Chinese and American biotechnology companies.

 

 

Research Focus

 

  • Bioengineering of biosynthetic enzymes and pathways for microbial production of biofuels;
  • Fungal cellulases;
  • Exploring novel biocatalysts from diverse biosynthetic systems of secondary metabolites through genome mining and biochemicalcharacterization;
  • Industrial strain improvement.

 

 

Selected Publications

 

 

  • Zhang W., Fortman, J. L., Carlson, J. C., Yan, J., Liu, Y., Bai, F., Guan, W., Jia, J., Matainaho, T., Sherman, D. H.*, and Li, S.* Characterization of the bafilomycin biosynthetic gene cluster from Straptomyces lohii. Chembiochem, 2013, 14(3), 301-306.
  • Li, S., Tietz, D. R., Rutaganira, F. U., Kells, P. M., Anzai, Y., Kato, F., Pochapsky, T. C., Sherman, D. H., and Podust, L. M.*
    Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions. J. Biol. Chem. 2012, 287(45), 37880-37890.
  • Li, S., Anand, K., Tran, H., Yu, F., Finefield, J. M., Sunderhaus, J. D., McAfoos, T. J., Tsukamoto, S., Williams, R. M., and
    Sherman, D. H.* Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways. MedChemComm 2012, 3(8), 987-996.
  • Li, S., Finefield, J. M., Sunderhaus, J. D., McAfoos, T. J., Williams, R. M., and Sherman, D. H.* Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids. J. Am. Chem. Soc. 2012, 134(2), 788-791.
  • Carlson, J. C.#, Li, S. #, Gunatilleke, S. S., Anzai, Y., Burr, D. A., Podust, L. M., and Sherman, D. H.* Tirandamycin biosynthesisis mediated by co-dependent oxidative enzymes. Nat. Chem. 2011, 3(8), 628-633. (#Co-first authors)
   
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