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    ZHANG Haibo
    Update time: 2018-10-15
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    ZHANG Haibo

    Title: Professor, Fine Chemicals Group

    Tel.: +86-532-58568203

    Email: zhanghb@qibebt.ac.cn 

    Address: 189 Songling Road, Qingdao, China, 266101 



    ZHANG Haibo obtained his Ph.D in microbiology from State Key Laboratory of Microbial Technology, Shandong University in 2010.In July 2010, he joined Qingdao Institute of Bioenergy and Bioprocess Technology, CAS as a faculty member. From 2013 to 2017, he worked as an associate Professor in the Biobased Materials department. He visited Massachusetts Institute of Technology as a visiting scholar in 2016. He is currently a professor and the leader of Fine Chemicals group. He has published over 30 research papers on leading journals such as Biotechnology for Biofuels, Macrobial Cell Factories and etc, and applied for more than 14 patents. He got the “Min Enze Energy and Chemical Progress Award for Young Scholar” in 2017.

    Research Interests 

    1) Biosynthesis of basic fine chemicals, such as isoprene, 2,3-butanediol, styrene and 2-phenylethanol, in engineered microorganisms.

    2) Biosynthesis of terpene-based high-density biofuels, such as pinene, sabinene, farnesene and terpinene, in engineered microorganisms.

    3) Developing biosensor, bacterial microcompartments and phospholipid metabolism regulation technologies for enhancing terpene production in engineered microorganisms.


    1. Changqing Liu, Xiao Men, Hailin Chen, Meijie Li, Zhaorui Ding, Guoqiang Chen, Fan Wang, Haobao Liu, Qian Wang, Youshuang Zhu, Haibo Zhang*, Mo Xian*. (2018). A systematic optimization of styrene biosynthesis in Escherichia coli BL21(DE3). Biotechnology for Biofuels, 11, 14

    2. Hailin Chen, Meijie Li, Changqing Liu, Haibo Zhang*, Mo Xian*, Huizhou Liu. (2018). Enhancement of the catalytic activity of isopentenyl diphosphate isomerase (idi) from Saccharomyces cerevisiae through random and site-directed mutagenesis. Microbial Cell Factories, 17, 65

    3. Meijie Li, Rui Nian, Mo Xian, Haibo Zhang*. (2018). Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli. Applied Microbiology and Biotechnology, Doi: 10.1007/s00253-018-9200-5

    4. Chang Qi, Hongwei Zhao, Wenyang Li, Xing Li, Haiying Xiang, Ge Zhang, Haobao Liu,* Qian Wang, Yi Wang, Mo Xian*, Haibo Zhang*. (2018). Production of ?-terpinene by metabolically engineered Escherichia coli using glycerol as feedstock. RSC Advances, 8, 30851

    5. Hailin Chen, Changqing Liu, Meijie Li, Haibo Zhang*, Mo Xian*, Huizhou Liu. (2018). Directed evolution of mevalonate kinase in Escherichia coli by random mutagenesis for improved lycopene. RSC Advances, 8, 15021-15028

    6. Hongwei Zhao, Jian Xia, Jiming Wang, Xiaofei Yan, Cong Wang, Tingzhou Lei, Mo Xian, Haibo Zhang*. (2018). Production of bacterial cellulose using polysaccharide fermentation wastewater as inexpensive nutrient sources. Biotechnology & Biotechnological Equipment, 32, 1-7

    7. Fan Wang, Hongwei Zhao, Haiying Xiang, Lijun Wu, Xiao Men, Chang Qi, Guoqiang Chen, Haibo Zhang*, Yi Wang*, Mo Xian*. (2018). Species diversity and functional prediction of surface bacterial communities on aging flue-cured tobaccos. Current Microbiology, 75, 1306?315

    8. Changqing Liu, Kai Zheng, Ying Xu, Lacmata Tamekou Stephen, Jiming Wang, Hongwei Zhao, Tongqing Yue, Rui Nian, Haibo Zhang*, Mo Xian*, Huizhou Liu*. (2017). Expression and characterization of soybean seed coat peroxidase in Escherichia coli BL21(DE3). Preparative Biochemistry & Biotechnology, 47, 768-775

    9. Hongwei Zhao, Jingyuan Li, Jiming Wang, Xin Xu, Mo Xian, Huizhou Liu, Haibo Zhang*. (2017). Calcium supplementation abates the inhibition effects of acetic acid on Saccharomyces cerevisiae. Applied Biochemistry & Biotechnology, 181, 1-17

    10. Haibo Zhang, Qiang Liu, Yujin Cao, Xinjun Feng, Yanning Zheng, Huibin Zou, Hui Liu, Jianming Yang*, Mo Xian*. (2014). Microbial production of sabinene--a new terpene-based precursor of advanced biofuel. Microbial Cell Factories, 13, 20-20

    11. Haibo Zhang, Mingle Cao, Xinglin Jiang, Huibin Zou, Cong Wang, Xin Xu, Mo Xian*. (2014). De-novo Synthesis of 2-Phenylethanol by Enterobacter sp. CGMCC 5087. BMC Biotechnology, 14, 30

    12. Jianming Yang, Qingjuan Nie, Meng Ren, Hongru Feng, Xinglin Jiang, Yanning Zheng, Min Liu, Haibo Zhang*, Mo Xian*. (2013). Metabolic engineering of Escherichia coli for the biosynthesis of alpha-pinene. Biotechnology for Biofuels, 6, 60-60


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